HPE ProLiant DL385 Gen10 PLUS v2 Server GPU Upgrades
Increase and update your business infrastructure by upgrading the GPU of your HPE ProLiant DL385 Gen10 PLUS v2 server. Upgrading to a pro NVIDIA GPU enhances your workflow with faster perfomance, superior graphics, and essential AI capabilities for business applications like data analytics, AI/ML platforms, design and engineering software, and video content creation tools.
HPE ProLiant DL385 Gen10 PLUS v2 GPU Configuration
The HPE ProLiant DL385 Gen10 PLUS v2 is a single-processor GPU server designed for high density acceleration workloads, offering 3 PCIe 4.0 x16 dual-slot or 3 PCIe 4.0 single-slot GPU cards for maximum compute expansion. The system provides abundant PCIe lanes and bandwidth to drive multiple enterprise-grade GPUs simultaneously, making it ideal for AI/ML training, data analytics, rendering, and other GPU-accelerated business applications. The ProLiant DL385 Gen10 PLUS v2 delivers the reliability, throughput, and scalability required for modern compute-intensive workflows in enterprise and datacenter environments.
The total number of GPU slots for the HPE ProLiant DL385 Gen10 PLUS v2 server is 3 for dual-slot or 3 single-slot cards, dual-slot and single-slot cards will run at x16 links. It is important to ensure that the PCIe generation is identical to the generation supported by the CPU.
The HPE ProLiant DL385 Gen10 PLUS v2 server supports PCIe 4.0 slots for the GPU. PCIe 5.0 GPUs may be supported but performance will decrease to PCIe 4.0 levels.
Ensure your chassis supports full-length / full-height or double-wide GPUs if needed. Note that some servers only support passive-cooled (blower) data-center GPUs such as NVIDIA A100/T4/L40/L40S/H100 etc.
Buy “HPE ProLiant DL385 Gen10 PLUS v2” GPUs today from Cloud Ninjas!
We recommend that you confirm the power supply and CPU and can support the newer GPU to avoid botlenecks or installation issues. The HPE ProLiant DL385 Gen10 PLUS v2 has for GPU support, 2x Redundant 1000W/1600W/1800W/2200W 80 PLUS Titanium PSUs.
The memory generations supported by the HPE ProLiant DL385 Gen10 PLUS v2 are, GDDR6, and HBM2.
Upgrade to NVIDIA GPUs built for real-time ray tracing and high-speed viewports to speed up rendering and design workflows in apps like Blender, Maya, SolidWorks, and AI content creation.
The HPE ProLiant DL385 Gen10 PLUS v2 can support GPUs of 48GB of VRAM, keep in mind some GPUs have NVLink bridges as perform much better than non NVLink GPUs, hence the higher the VRAM the more performance you get on your AI GPU cluster.
Cloud Ninjas's HPE ProLiant DL385 Gen10 PLUS v2 Q&A
1. What are the benefits of upgrading to a enterprise NVIDIA GPU? Upgrading to a professional NVIDIA GPU improves performance, stability, and eficiency in AI, 3D design, video editing, and simulation workflows. Get your GPUs at https://cloudninjas.com/.
2. How do I know if I need a GPU upgrade? If you are experiencing slow rendering times, or performance bottlenecks, it is a strong sign your GPU needs upgrading. When upgrading, it is strongly recommended to ensure the PCIe interface of your upgrade matches the interface on your system. It is also recommended to ensure the power supply will be compatible with the GPU, and GPUs in total should be under the total PSU power, do not forget to consider the CPU and other components for power consumption and choosing your GPU card.
3. Which NVIDIA GPU is best for AI and machine learning? GPUs with strong Tensor core perfomance and high VRAM such as the NVIDIA RTX Pro and A-series deliver superior AI training and inference performance because they are specifically engineered to accelerate deep learning workloads. These GPUs combine advanced matrix-processing Tensor cores with fast GDDR6/GDDR7 or HBM memory to maximize throughput, support larger AI models, enable higher batch sizes, and maintain scalable performance during long training sessions. As a result, NVIDIA enterprise GPUs provide faster neural network training, lower latency, and significantly improved scalability for machine learning, computer vision, and generative AI applications.
4. How much VRAM do I need for professional workloads? Most AI, 3D, and simulation workloads run best with 16-24GB of VRAM or more, especially when working with large models or complex scenes.
5. Will upgrading my GPU improve 4K or 8K video editing? Yes. Modern GPUs with updated NVENC/NVDEC encoders greatly improve editing, playback, and thermal requirements.
6. What hardware do i need to check before upgrading my GPU? Ensure your power supply, cooling system, and case size can support the new GPU's power draw and thermal requirements. In order to see the most improvement from your upgrade, ensure the PCIe generations match on your GPU and your system's motherboard.
7. Can an older CPU bottleneck a new GPU? Yes. if your CPU is outdated, it may limit the performance of a newer GPU, especially in AI training and graphics heavy tasks.
8. Are NVIDIA enterprise GPUs better for business software? Yes. Professional NVIDIA GPUs are ISV-certified for applications like AutoCAD, SolidWorks, and Adobe, ensuring maximum performance and reliability. The NVIDIA GPUs are also ideal for softwares that run LLMs locally such as LM Studio or Abacus.AI. Learn more about ISV certifications here
9. Do GPU upgrades help with engineering simulations? High bandwidth, ECC enabled GPUs significantly speed up engineering and scientific simulations by providing fast, reliable memory access that reduces cmputation time and prevents data corruption. In applications like ANSYS, MATLAB, COMSOL, and other CAE tools, GPUs with high memory bandwidth and ECC VRAM deliver more accurate simulation results, faster parallel processing and greater numerical stability. This is especially true when running large finite-element models, multiphysics simulations, or data-intensive mathematical workloads. This combination of speed and reliability makes professional GPUs essential for engineers, researchers, and scientists who need consitstent performance and trustworthy results in their simulation environments.
10. How often should businesses upgrade their GPUs? Most companies upgrade every 3-5 years to stay compatible with modern software and maintain competitive performance. It is recommended to have a yearly assessment for potential upgrades based on the business' AI workloads.
11. What's the difference between consumer and professional NVIDIA GPUs? Professional GPUs offer ECC memory, long term driver support, and certifications for engineering and design software. These features are critical for businesss reliability.
12. Do I need multiple GPUs for AI or rendering?Multi GPU setups benefit heavy AI training, simulations, and large scale rendering. Many businesses see major gains from just one powerful upgrade.
13. Will uprading my GPU reduce downtime?Yes. Newer GPUs provide better stability, fewer crashes, and improved driver support, which helps keep workflows running smoothly.
14. Do I need to update drivers after installing a new GPU?Absolutely. Up to date NVIDIA drivers ensure optimal perofmance, compatibility, and reliability across professional applications.
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The total number of GPU slots for the HPE ProLiant DL385 Gen10 PLUS v2 server is 3 for dual-slot or 3 single-slot cards, dual-slot and single-slot cards will run at x16 links. It is important to ensure that the PCIe generation is identical to the generation supported by the CPU.
The HPE ProLiant DL385 Gen10 PLUS v2 server supports PCIe 4.0 slots for the GPU. PCIe 5.0 GPUs may be supported but performance will decrease to PCIe 4.0 levels.
Ensure your chassis supports full-length / full-height or double-wide GPUs if needed. Note that some servers only support passive-cooled (blower) data-center GPUs such as NVIDIA A100/T4/L40/L40S/H100 etc.
Buy “HPE ProLiant DL385 Gen10 PLUS v2” GPUs today from Cloud Ninjas!
The memory generations supported by the HPE ProLiant DL385 Gen10 PLUS v2 are, GDDR6, and HBM2.
Upgrade to NVIDIA GPUs built for real-time ray tracing and high-speed viewports to speed up rendering and design workflows in apps like Blender, Maya, SolidWorks, and AI content creation.